Publications

IQ MPS is developing series of organotypic manuscripts for publication in Lab on a Chip (Impact factor: 6.914). The purpose of the manuscript series is to specifically outline the contemporary pharmaceutical industry perspectives and considerations for developing, evaluating, and characterizing MPS models to support drug discovery and development.

Introduction

Fabre, K., Berridge, B., Proctor, W., Ralston, S., Will, Y., Baran, SW., Yoder, G., Van Vleet, T. (2019) An Introduction to the Characterization and Use of Microphysiological Systems (MPS) in Pharmaceutical Safety and ADME Applications. Lab on a Chip.  Available here.

Lung

Ainslie, G. R., Davis, M., Ewart, L., Lieberman, L. A., Rowlands, D. J., Thorley, A. J., ... & Ryan, A. M. (2019). Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective,  9(19), 3152-61. DOI: 10.1039/C9LC00492K.  Lab on a Chip.  Available here.

Skin

Hardwick, R.N., Betts, C.J., Whritenour, J., Sura, R., Thamsen, M., Kaufman E., Fabre K., (2019) Drug-Induced Skin Toxicity: Gaps in Preclinical Testing Cascade as Opportunities for Complex In Vitro Models and Assays, DOI: 10.1039/c9lc00519f​  Lab on a Chip.  Available here.

Liver

Baudy, A.R., Otieno, M.A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T.R., Proctor, W.R., (2019) Liver Microphysiological Systems Development Guidelines for Safety Risk Assessment in the Pharmaceutical Industry.​  Lab on a Chip.  Available here.

Kidney

Philips, J.A., Grandhi, T.S.P., Davis, M., Gautier, J.C., Hariparsad, N., Keller, D., Sura, R., Van Vleet, T. (2019) A Pharmaceutical Industry Perspective on Microphysiological Kidney Systems for Evaluation of New Therapies. Lab on a Chip. Available here.

ADME

Fowler, S., Chen, W.L.K., Duigan, D., Gupta, A., Hariparsad, N., Kenny, J., Lai, G., Liras, J., Phillips, J., Gan, J. (2019) Microphysiological Systems for ADME-Related Applications: Current Status and Recommendations for System Development and Characterisation, Lab on Chip.  Available here..

Biologics

Peterson, N., Mahalingaiah, P. K., Fullerton, A., Di Piazza, M. (2019) Application of 3D Cultures and Microphysiological Systems in Biopharmaceutical Research and Development. Lab on a Chip.  Available here.

CNS/BBB

Under Development

Cardiovascular

Under Development

Gastrointestinal

Peters, M., Choy, A., Pin, C., Leishman, D., Moisan. A., Ewart, L., Guzzie-Peck, P., Sura, R., Keller, D., Scott, C., Kolaja, L. (2019) Developing in vitro Assays to Transform Gastrointestinal Safety Assessment: Potential for Microphysiological Systems. Lab on Chip.  Available here.

Past Working Group Publications