
IQ MPS
IQ Microphysiological Systems Affiliate
An Affiliate of the International Consortium for Innovation and Quality in Drug Development
Publications
Utility of Animal Cell-Based Microphysiological Systems to Support Human Drug Development
Devine, P. J., Ekert, J., Kopec, A. K., Stresser, D. M., Ramsden, D., Szilagyi, J., Hewitt, P., Hardwick, R. N., Laing, S., Van Vleet, T. R., Moalli, M., & Bajaj, P. (2025). Pharmaceutical industry perspective on the utility of animal cell-based microphysiological systems to support human drug development. ALTEX, 10.14573/altex.2407122.

Jul 25, 2025
Exploring the synergy of CRISPR and microphysiological systems
Celauro, E., Saleh, A. F., Mahalingaiah, P. K., Mohamet, L., David, R., & Nitsch, R. (2025). Exploring the synergy of CRISPR and microphysiological systems. ALTEX - Alternatives to Animal Experimentation. https://doi.org/10.14573/altex.2403251

May 9, 2025
2023 IQ MPS | FDA Workshop - Roles of Animal-cell Based MPS in Drug Discovery and Development and 3Rs Applications of MPS
Devine, P. J., Guha, M., Ekert, J. E., Kopec, A. K., Gosset, J. R., Freag, M. S., Wagoner, M. P., Hewitt, P., Harris, K., Lemmens, M., Sadrieh, N., et al. (2025). Considerations from the pharmaceutical industry (IQ MPS Affiliate) workshop on animal microphysiological systems and 3Rs in drug development. ALTEX – Alternatives to Animal Experimentation.

Apr 11, 2025
Cell Therapies
Candarlioglu, P. L., Delsing, L., Gauthier, L., Lewis, L., Papadopoulos, G., Freag, M., Chan, T. S., Homan, K. A., Fellows, M. D., Pointon, A. (2024) Application of Microphysiological Systems for Nonclinical Evaluation of Cell Therapies. ALTEX Alternatives to animal experimentation

Jul 16, 2024
Landscape Survey
Baker, T. K., Van Vleet, T. R., Mahalingaiah, P. K., Grandhi, T. S. P., Evers, R., Ekert, J., Gosset, J. R., Chacko, S. A., & Kopec, A. K. (2024). The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary. Drug metabolism and disposition: the biological fate of chemicals, 52(3), 198–209.

Feb 14, 2024
In Vitro Models for Reducing or Replacing Animal Models
Stresser, D. M., Kopec, A. K., Hewitt, P., Hardwick, R. N., Van Vleet, T. R., Mahalingaiah, P. K. S., ... & Homan, K. A. (2023). Towards in vitro models for reducing or replacing the use of animals in drug testing. Nature Biomedical Engineering, 1-6.

Dec 27, 2023
2021 IQ MPS | FDA Workshop - Standardization of Complex In Vitro Models in Drug Development
Tomlinson, L., Ramsden, D., Leite, S. B., Beken, S., Bonzo, J. A., Brown, P., ... & Hardwick, R. N. (2023). Considerations from an international regulatory and pharmaceutical industry (IQ MPS Affiliate) workshop on the standardization of complex in vitro models in drug development. Advanced Biology, 2300131.

Oct 9, 2023
Immune System
Wang, X., Kopec, A., Collinge, M., David, R., Grant, C., Hardwick, R., Navratil, A., Patel, N., Rowan, W. and Marshall, N. (2022) Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations. ALTEX - Alternatives to animal experimentation.

Mar 29, 2023
Oligonucleotides
Ramsden, D., Belair, D. G., Agarwal, S., Andersson, P., Humphreys, S., Dalmas, D. A., ... & Cichocki, J. A. (2022) Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics. ALTEX-Alternatives to animal experimentation.

Apr 11, 2022
2020 IQ MPS | FDA Workshop - Perspectives on the evaluation and adoption of complex in vitro models in drug development
Baran, S. W., Brown, P. C., Baudy, A. R., Fitzpatrick, S. C., Frantz, C., Fullerton, A., … Ekert, J. E. (2022). Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate). ALTEX - Alternatives to Animal Experimentation, 39(2), 297–314

Apr 11, 2022
MPS Organotypic Manuscript 1.0 Introduction
Fabre, K., Berridge, B., Proctor, W., Ralston, S., Will, Y., Baran, SW., Yoder, G., Van Vleet, T. (2019) An Introduction to the Characterization and Use of Microphysiological Systems (MPS) in Pharmaceutical Safety and ADME Applications. Lab on a Chip.

Feb 10, 2020
Navigating Tissue Chips from Development to Dissemination
Ewart, L., Fabre, K., Chakilam, A., Dragan, Y., Duignan, D. B., Eswaraka, J., Gan, J., Guzzie-Peck, P., Otieno, M., Jeong, C. G., Keller, D. A., de Morais, S. M., Phillips, J. A., Proctor, W., Sura, R., Van Vleet, T., Watson, D., Will, Y., Tagle, D., & Berridge, B. (2017). Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective. Experimental biology and medicine (Maywood, N.J.), 242(16), 1579–1585.

Jun 16, 2017

