IQ MPS is developing series of organotypic manuscripts for publication in Lab on a Chip (Impact factor: 6.914). The purpose of the manuscript series is to specifically outline the contemporary pharmaceutical industry perspectives and considerations for developing, evaluating, and characterizing MPS models to support drug discovery and development.


Fabre, K., Berridge, B., Proctor, W., Ralston, S., Will, Y., Baran, SW., Yoder, G., Van Vleet, T. (2019) An Introduction to the Characterization and Use of Microphysiological Systems (MPS) in Pharmaceutical Safety and ADME Applications. Lab on a Chip.  Available here.


Ainslie, G. R., Davis, M., Ewart, L., Lieberman, L. A., Rowlands, D. J., Thorley, A. J., ... & Ryan, A. M. (2019). Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective,  9(19), 3152-61. DOI: 10.1039/C9LC00492K.  Lab on a Chip.  Available here.


Hardwick, R.N., Betts, C.J., Whritenour, J., Sura, R., Thamsen, M., Kaufman E., Fabre K., (2019) Drug-Induced Skin Toxicity: Gaps in Preclinical Testing Cascade as Opportunities for Complex In Vitro Models and Assays, DOI: 10.1039/c9lc00519f​  Lab on a Chip.  Available here.


Baudy, A.R., Otieno, M.A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T.R., Proctor, W.R., (2019) Liver Microphysiological Systems Development Guidelines for Safety Risk Assessment in the Pharmaceutical Industry.​  Lab on a Chip.  Available here.


Philips, J.A., Grandhi, T.S.P., Davis, M., Gautier, J.C., Hariparsad, N., Keller, D., Sura, R., Van Vleet, T. (2019) A Pharmaceutical Industry Perspective on Microphysiological Kidney Systems for Evaluation of New Therapies. Lab on a Chip. Available here.


Fowler, S., Chen, W.L.K., Duigan, D., Gupta, A., Hariparsad, N., Kenny, J., Lai, G., Liras, J., Phillips, J., Gan, J. (2019) Microphysiological Systems for ADME-Related Applications: Current Status and Recommendations for System Development and Characterisation, Lab on Chip.  Available here..


Peterson, N., Mahalingaiah, P. K., Fullerton, A., Di Piazza, M. (2019) Application of 3D Cultures and Microphysiological Systems in Biopharmaceutical Research and Development. Lab on a Chip.  Available here.


Under Development


Under Development


Peters, M., Choy, A., Pin, C., Leishman, D., Moisan. A., Ewart, L., Guzzie-Peck, P., Sura, R., Keller, D., Scott, C., Kolaja, L. (2019) Developing in vitro Assays to Transform Gastrointestinal Safety Assessment: Potential for Microphysiological Systems. Lab on Chip.  Available here.

Past Working Group Publications

Manuscripts Open Access

IQ MPS Affiliate manuscripts published in Lab on a Chip are now available as a special edition of the Journal. Find the full special collection here.