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News and Events

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  • (OCT 2023) IQ MPS Affiliate Welcomes New Member Company
    The IQ MPS Affiliate is excited to welcome its newest member, Daiichi Sankyo! Daiichi Sankyo is a global pharmaceutical company with corporate origins in Japan. We provide innovative products and services in 29 countries/regions around the world. With more than 120 years of scientific expertise, our company draws upon a rich legacy of innovation and a robust pipeline of promising new medicines to help patients. Daiichi Sankyo will be represented on the IQ MPS Steering Committee by Thomas Fischer.
  • (OCT 2023) NEW PUBLICATION - “Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development” | Advanced Biology
    In May 2022, there was an International Regulatory and Pharmaceutical Industry (Innovation and Quality [IQ] Microphysiological Systems [MPS] Affiliate) Workshop on the standardization of complex in vitro models (CIVMs) in drug development. This manuscript summarizes the discussions and conclusions of this joint workshop organized and executed by the IQ MPS Affiliate and the United States Food and Drug Administration (FDA). Read more here.
  • (APR 2023) IQ MPS Affiliate Welcomes New Member Company
    The IQ MPS Affiliate is excited to welcome its newest member, Servier! Servier is a privately held international pharmaceutical company headquartered in France with a passion for innovation that has improved patients’ lives around the world. Servier will be represented on the IQ MPS Steering Committee by Chloe Korlowski and Amelie Moreau.
  • (MAR 2023) IQ MPS Affiliate Welcomes New Member Company
    The IQ MPS Affiliate is excited to welcome its newest member, Roche! Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. Roche will be represented on the IQ MPS Steering Committee by Nadine Stokar and Remi Villenave.
  • (FEB 2023) NEW PUBLICATION - “Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges” | ALTEX - Alternatives to animal experimentation
    In this manuscript, the authors provide a pharmaceutical industry perspective on the state of the science of MPS disease models, including models for cancer, liver/kidney diseases, respiratory diseases, neurodegenerative diseases, gastrointestinal diseases, and select rare diseases. The authors also describe their technical limitations and provide recommendations for future model development that would expand application opportunities within the pharmaceutical industry. Read more here.
  • (JAN 2023) IQ MPS Affiliate Welcomes New Member Company
    The IQ MPS Affiliate is excited to welcome its newest member, Incyte! Incyte is a global biopharmaceutical company focused on finding solutions for serious unmet medical needs through the discovery, development and commercialization of novel medicines. Incyte will be represented on the IQ MPS Steering Committee by Manti Guha and Alejandro Amador.
  • (JUL 2022) IQ MPS Affiliate Welcomes New Member Company
    The IQ MPS Affiliate is excited to welcome its newest member, UCB! UCB Pharma is a leading global biopharmaceutical company focused on creating value for people living with severe diseases in immunology and neurology now and into the future. UCB Pharma will be represented on the IQ MPS Steering Committee by Jason Ekert.
  • (MAY 2022) The IQ MPS Affiliate and FDA Organize their 2ND WORKSHOP, this time with GLOBAL REGULATORS, to Discuss the Development of Performance Standards and Guidelines for the Qualification of MPS Technologies
    On May 23 and 24, up to 200 representatives from US FDA, the IQ MPS Affiliate, and various global regulatory agencies and standards-setting organizations met virtually to discuss the development of performance standards and guidelines for Microphysiological Systems in drug development. Many thanks to the US FDA and IQ MPS representatives who helped organize this event and our panelists, speakers, and moderators for making this an informative and productive workshop. A manuscript summarizing the proceedings, including lessons learned and recommendations, is forthcoming!
  • (FEB 2022) NEW PUBLICATION - "Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)" | ALTEX - Alternatives to animal experimentation
    Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/or efficacy, but for this technology to have an impact, the establishment of robust characterization and qualification plans constructed around specific context of use (COU) are required. This perspective article will cover the important output from a workshop between the Food and Drug Administration (FDA) and Innovation and Quality Microphysiological Systems (IQ MPS) Affiliate. Read more here.
  • (JULY 2021) IQ MPS Affiliate Welcomes New Member Company
    IQ MPS Affiliate welcomes Boehringer Ingelheim as the newest member of the Affiliate. Contact us to learn more about how your company can join and collaborate in the MPS Affiliate.
  • (JAN 2021) NEW PUBLICATION - "Cardiovascular Microphysiological Systems (CVMPS) for Safety Studies- A Pharma Perspective." | Lab on a Chip"
    The IQ MPS Affiliate announces its 8th manuscript in Lab on a Chip, “Cardiovascular Microphysiological Systems (CVMPS) for Safety Studies- A Pharma Perspective.” To enable to the adoption of CVMPS for evaluating novel drug candidates, industry will need evidence of their “fit for purpose” applications targeted at different levels of complexity and integration. Meeting this challenge will require development of mature bioengineered components with meaningful vascular linkages that provide more value than current in vivo models, an effort best served by partnerships between government-funded initiatives, academics, and private companies. Read the publication here.
  • (JUN 2020) - CALLING ALL GI MPS Developers - the IQ MPS Affiliate's GI RFI is now available!
    See Projects to learn more!
  • (FEB 2020) NOW AVAILABLE IN ‘LAB ON A CHIP’ - IQ MPS Organotypic Manuscript Special Collection
    IQ Microphysiological Systems (MPS) Affiliate manuscripts published in Lab on a Chip are now available as a special online edition of the Journal. Manuscripts contain information on likely initial contexts of use (CoU) for MPS and key characterization data needed for incorporation of these tools in pharmaceutical safety screening and drug development. Individual manuscripts also provide a list of characteristic functions, cell types, toxicities, and test agents that can serve as a guide for developers of lung, liver, skin, kidney, and gastrointestinal MPS as well as MPS for applications in biologics drug development and ADME. For more information, read the introductory manuscript here. Find the full special collection here.
  • (FEB 2020) NEW PUBLICATION - “Developing in vitro Assays to Transform Gastrointestinal Safety Assessment: Potential for Microphysiological Systems” | Lab On A Chip
    To guide the design of GI-MPS assays to meet safety assessment needs for drug-induced gastrointestinal toxicities, this review provides an industry perspective on assay features of high priority. The topics discussed include screening assays for early detection, investigative models for mechanistic elucidation, tool compounds for assessing predictive performance, gaps and opportunities emerging with epithelial-only GI microtissues, specific microphysiologies that need to be emulated to align with top GI AEs, kinetic data to support mathematical modelling, and guidance on assay endpoint selection. Read more here.
  • (JAN 2020) NEW PUBLICATION - “A Pharmaceutical Industry Perspective on Mircrophysiological  Kidney Systems for Evaluation of New Therapies” | Lab On A Chip
    Pharmaceutical industry scientists provide their perspective on the phenotypic and physiochemical attributes of microphysiological kidney models that could improve confidence in safety and ADME evaluations of experimental therapies and key considerations for effectively implementing these models in nephrotoxicity testing. Read the publication here .
  • (JAN 2020) NEW PUBLICATION - “Application of 3D Cultures and Microphysiological Systems in Biopharmaceuticals Research and Development.” | Lab On A Chip
    IQ MPS Affiliate scientists describe the opportunities and challenges in developing tissue-specific MPS for preclinical research of large molecule therapeutics. Read more here .
  • (JAN 2020) NEW PUBLICATION - “Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization” | Lab On A Chip
    This manuscript provides a pharmaceutical industry perspective on qualification standards and future directions for contemporary complex in vitro models in ADME applications with a focus on four organs of interest (liver, intestine, kidney, and brain) and linked-organ systems. Read more here.
  • (DEC 2019) NEW PUBLICATION - “Liver Microphysiological Systems Development Guidelines for Safety Risk Assessment in the Pharmaceutical Industry” | Lab On A Chip
    In this manuscript, pharmaceutical industry scientists describe a 3-part strategy for optimizing and bench-marking liver MPS performance, so as to help model developers and end users identify what would be the most valuable models for safety risk assessment. This critical review also describes all of the features of the ideal liver MPS model, provides an overview of currently used safety assays, and highlights the best-suited contexts of use for various liver MPS categories. Read more here .
  • (OCT 2019) NEW PUBLICATION - “Drug-Induced Skin Toxicity: Gaps in Preclinical Testing Cascade as Opportunities for Complex In Vitro Models and Assays.” | Lab On A Chip
    In this manuscript, pharmaceutical industry scientists provide an overview of current complex skin model capabilities and limitations within the drug development scheme. Recommendations are also provided for future model development and assay qualification with the intent to facilitate wider adoption within the pharmaceutical industry. Read more here.
  • (AUG 2019) NEW PUBLICATION - “Microphysiological Lung Models to Evaluate the Safety of New Pharmaceutical Modalities: A Biopharmaceutical Perspective” | Lab On A Chip
    This article summarizes, from a biopharmaceutical industry perspective, essential elements for the development and qualification of lung MPS models. Its purpose is to guide MPS developers and manufacturers to expedite MPS utilization for safety assessment in the biopharmaceutical industry. Read more here
  • (AUG 2019) The IQ MPS Affiliate to Publish a Series of Organotypic Manuscripts in the Royal Society of Chemistry's | Lab On A Chip
    Scientists from several biopharmaceutical companies, through the International Consortium for Innovation and Quality in Pharmaceutical Development Microphysiological Systems (IQ MPS) Affiliate, will prepare a series of organotypic manuscripts to provide relevant information to MPS developers and users on the characterization parameters and data needed to expedite implementation of MPS in safety screening in drug discovery and development. Individual manuscripts will provide information on the cell types and tissue functions, test agents (representing major mechanisms of toxicity), relevant assessment endpoints/biomarkers and likely initial contexts of use, with the intent that MPS developers incorporate these into their models to facilitate uptake of MPS platforms by the biopharmaceutical industry and health authorities/regulators. Manuscripts will focus on lung, liver, kidney, skin, gastrointestinal, cardiovascular, and blood brain barrier/central nervous system. In addition, an introductory article and two manuscripts focusing on biologically-based therapeutics and ADME considerations will be prepared as part of this effort. These manuscripts will be published in Lab on a Chip.
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